Critical site bleeds: Intracranial hemorrhage, including intraparenchymal, subdural, epidural, and subarachnoid hemorrhages; Other CNS hemorrhage, including intraocular, intra- or extra-axial spinal hemorrhages; Pericardial tamponade; Airway, including posterior epistaxis; Hemothorax, intraabdominal bleeding, and retroperitoneal hemorrhage; Extremity bleeds, including intramuscular and intraarticular bleeding concerning for compartment syndrome, bleeding associated with hemodynamic instability, bleeding in a noncompressible vessel (e.g., subclavian)

No reversal agent is currently available. May consider recombinant human coagulation Factor VIIa (rFVIIa, NovoSeven) 90 micrograms/kg IV for life-threatening bleeding (rVIIa will not affect anti-Xa activity and will not increase drug clearance).