Currently not available in the United States

Mechanism of Action

• Anti-thrombin mediated inhibition of factor Xa

Half-Life

• 82 min

Metabolism

• Renal excretion

Dosing – Adult

• S.C.: 175 anti-Xa units/kg daily

Dosing – Pediatric

• Safety, dosing and efficacy in pediatric patients not established
• S.C.:
  • ≤ 2 months of age 275 IU/kg daily
  • 2-12 months of age 250 IU/kg daily
  • 1-5 years 240 IU/kg daily
  • 5-10 years 200 IU/kg daily
  • 10-16 years 175 IU/kg daily

Monitoring

• Not required
• Can use: Antifactor Xa using drug specific curve