FVIII & FIX Deficiency with inhibitors Takeda Standard t1/2HALF LIFE (hours): 4-7 hours;based on thrombin generation Plasma-derived(Activated PCC) Dosing Calculation Topic Dose Bleed 50-100 IU/kg Q 6-12 hours Prophylaxis 85 IU/kg every other day Administer dose over ~20-30 minutesMax single dose: 100 IU/kgMax daily dose: 200 IU/kg Notes Warning: Contains FIX. Patients with FIX […]
Congenital Hemophilia A or B with inhibitors HEMA Biologics, LLC Standard t1/2HALF LIFE (hours): 1.4 – 1.7 hours Recombinant 2nd Gen – transgenic rabbits Cell Type: human FVII protein expressed in mammary gland of genetically engineered rabbits Dosing Calculation Topic Dose Mild to moderate bleeding episodes 75 mcg/kg Q 3 hours until hemostasis is achieved or Initial […]
FVII Deficiency, Hemophilia A or B with inhibitors, Glanzmann’s Thrombasthenia, acquired hemophilia Novo Nordisk Standard t1/2HALF LIFE (hours): 2.6-3.1 Recombinant 2nd Gen Dosing Calculation Congenital Hemophilia A or B with Inhibitors: 90 mcg/kg every 2 hours, adjustable until hemostasis achieved. 90 mcg/kg every 3-6 hours after hemostasis is achieved for severe bleeds. Higher doses at less […]
Acquired Hemophilia Takeda Standard t1/2HALF LIFE (hours):10 hours, highly variable;Range 2.6-28.6 hrs Recombinant 2nd Gen (BDD) Porcine sequence FVIII Dosing Calculation Dosing Goals (FVIII Level):Dose every 4 to 12 hours. Titrate as needed to maintain FVIII levels. Topic Initial Dose Factor VIII level required Minor bleed – superficial muscle, joint 200 IU/kg 50-100 IU/dL Major […]
