Afibrinogenemia/Hypofibrinogenemia CSL Behring Standard t1/2HALF LIFE (hours):Age >16 yrs: 82.3 ± 20Age <16 yrs: 69.9 ± 8.5 Plasma-derived Dosing Calculation # mg = [ Target level mg/dL – Measured level mg/dL / 1.7] X weight (kg) When Fibrinogen level unknown: 70 MG/KG Monitoring Goals: Target fibrinogen level of 100 mg/dL should be maintained until hemostasis achieved. Notes Injection Rate: Should […]
Antithrombin III Deficiency rEVO Biologics Standard t1/2HALF LIFE:50 IU/kg: 11.6 hours100 IU/kg: 17.7 hours Transgenic Dosing Calculation Surgical patients:Loading dose:#Units = [100 – baseline AT activity / 2.3] X weight (kg) Maintenance dose (continuous infusion):#Units = [100 – baseline AT activity / 10] X weight (kg) Pregnant women:Loading dose:#Units = [100 – baseline AT activity / 1.3] X weight (kg) Maintenance dose (continuous infusion):#Units = [100 – […]
Antithrombin III Deficiency Grifols Standard t1/2HALF LIFE (days): 2.5-3.8 Plasma-derived Dosing Calculation # Units = [100 – baseline AT activity / 1.4] X weight (kg) Dosing goal: 80-120% Notes:Monitoring antithrombin: Baseline level 20 minutes post-infusion Q 12 hrs Recommended Dosing Guidelines Regimen (timing) Target AT Level Dose (Units) Monitor AT Level Loading Dose 120% of normal [120% – […]
Reversal of Vitamin K Antagonist-Induced Coagulopathy CSL Behring Standard t1/2HALF LIFE: FII: 59.7 hours FVII: 4.2 hoursFIX: 16.7 hours FX: 30.7 hours Plasma-derived(4-factor PCC) FIX:FII:FVII:FX = ~1:1:1:1 Product labeled in FIX units only Composition per vial of KCENTRA Ingredient Potency Range for 500 units Potency Range for 1000 units Total protein 120-280 mg 240-560 mg Factor […]
FII or FX Deficiency Grifols Standard t1/2HALF LIFE: FII: 3-4 days FIX: 18-24 hours Plasma-derived (PCC) FX: 40-60 hours FIX:FII:FX = 1:1.5:1 Product labeled in FIX units only Dosing Calculation FII: weight (kg) X % correction X VD (0.7)FX: weight (kg) X % correction X VD (1.0) *Dosing based on FIX labeled units Minimal hemostatic level: FII: ~30% FX: ~15-20% Infusion Rate: Not to exceed 10 mL/min […]
FV, FXI Deficiency Octapharma Standard t1/2FV: ~36 hours FXI: 40-70 hours Fresh Frozen Plasma Solvent-detergent treated Dosing Calculation 10-15 mL/kg (Approximately 3-5 units of FFP in adults); Expected coagulation factor level increase 15-25%. Higher doses if hemostasis is not achieved. Minimal hemostatic level: FV: ~15-20% FXI: ~15-20% Monitoring: PT (FV deficiency) PTT (FXI deficiency) Transfer Device Storage Store […]
FV, FXI Deficiency Standard t1/2 FV: ~36 hours Fresh Frozen Plasma FXI: 40-70 hours Dosing Calculation 10-15 mL/kg (Approximately 3-5 units of FFP in adults); Expected coagulation factor level increase 15-25%. Higher doses if hemostasis is not achieved. Minimal hemostatic level: FV: ~15-20% FXI: ~15-20% Monitoring: PT (FV deficiency) PTT (FXI deficiency) Transfer Device Storage Store […]
