Sanofi Recombinant Extended t1/2Fusion protein with D’D3 domain, IgG-1 Fc, two XTEN polypeptides 4th Gen HALF LIFE (hours): 1 – <6 yrs 39.9 6 – <12 yrs 42.4 12 – <18 yrs 44.6 18+ yrs 48.2 Dosing Calculation # Units = % correction X VD X weight (kg)*Written as Whole Number (50%=50) […]
Biogen Extended t1/2IgG-1 Fc-domain Recombinant Fusion Protein 4th Gen (BDD) HALF LIFE (hours):Adults: 19.7Peds:1 – 5 yrs: 12.76 – 11 yrs: 14.912 – 17 yrs: 16.4 Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose (Pediatric & Adult) IU/kg (% correction) Prophylaxis 50 (100%): Q 4 days Minor Bleed 20 (40%): […]
Novo Nordisk Extended t1/2O-glycoPEGylated Protein Recombinant HALF LIFE (hours): 3rd Gen Adult:≥ 18 yrs: 21.7Ped:1-5 yrs: 14.76-11 yrs: 13.812-17 yrs: 17.4 Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) <12 yrs ≥12 yrs Prophylaxis 65 IU/kg 2x/wk 50 IU/kg every 4 days Minor Bleed 20 (40%) 20 […]
Bayer Extended t1/2PEGylated Protein Recombinant HALF LIFE (hours): 3rd Gen ≥12 yrs: 17.9 Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) 7 to <12 yrs ≥12 yrs Prophylaxis 60 IU/kg 2x/wk 30-40 IU/kg 2x/wk Minor Bleed 20 (40%) 20 (40%) Major Bleed 40 (80%) 40 (80%) Notes […]
CSL Behring Extended t1/2HALF LIFE (hours): Recombinant Adults: 14.2 3rd Gen Peds:0 – 5 yrs: 10.46 – 11 yrs: 10.212 – 17 yrs: 14.3 Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) <12 yrs >12 yrs Prophylaxis 20-50 IU/kg 2 -3x/wk 30-50 IU/kg 2 – 3x/wk Minor […]
Baxalta Extended t1/2 Recombinant Pegylated ProteinHALF LIFE (hours):Adults: 14.69 3rd Gen (FLC) Peds:1 – 5 yrs: 11.86 – 11 yrs: 12.412 – 18 yrs: 13.43 Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) <12 yrs ≥12 yrs Prophylaxis 55-70 (110- 140%) 2 x/wk 40-50 (80- 100%) 2 […]
Octapharma Standard t1/2 HALF LIFE (hours): Recombinant Adult: 17.2 (highly variable)Peds: 2-5 yrs: 11.9; 6-12 yrs: 13.1 4th Gen (BDD) *Per IHTC dosing:Half-life for all FVIII Standard t1/2 products: ~12 hours Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) Prophylaxis 3x/week: 25/25/50 (50%/50%/100%) Minor Bleed 20 (40%) Major Bleed 40 […]
Bayer Standard t1/2 HALF LIFE (hours): Recombinant Adult: ≥12 yrs: ~14.2-14.4Peds: 0-12 yrs: ~12 hrs 3rd Gen (FLC) *Per IHTC dosing:Half-life for all FVIII Standard t1/2 products: ~12 hours Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) Prophylaxis 3x/week: 25/25/50 (50%/50%/100%) Minor Bleed 20 (40%) Major Bleed 40 (80%) Notes *FDA […]
Pfizer Standard t1/2 HALF LIFE (hours): Recombinant Adult: 11.2 + 5Peds: 8 + 2.4 3rd Gen (BDD) *Per IHTC dosing:Half-life for all FVIII Standard t1/2 products: ~12 hours Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) Prophylaxis 3x/week: 25/25/50 (50%/50%/100%) Minor Bleed 20 (40%) Major Bleed 40 (80%) Transfer Device […]
Novo Nordisk Standard t1/2HALF LIFE (hours): Recombinant Adult: 11-12Peds: 7.7-10 3rd Gen (BDT) *Per IHTC dosing:Half-life for all FVIII Standard t1/2 products: ~12 hours Dosing Calculation # Units = weight (kg) X % correction* X VD (0.5)*Written as Whole Number (50%=50) Topic Dose IU/kg (% correction) Prophylaxis 3x/week: 25/25/50 (50%/50%/100%) Minor Bleed 20 (40%) Major Bleed 40 (80%) Transfer Device Storage Refrigerate at […]
