Dose- Adult

Rivaroxaban > 10 mg or Apixaban > 5 mg given < 8 hours OR dose/timing unknown: 800 mg IV bolus administered at a rate of ~30 mg/minute, followed 2 minutes later by 8 mg/minute IV infusion for up to 120 minutes

Apixaban <5 mg  or Xarelto <10 mg given < 8 hrs, OR higher dose given > 8 hrs: 400 mg IV bolus administered at a rate of ~30 mg/minute, followed 2 minutes later by 4 mg/minute IV infusion for up to 120 minutes