Mechanism of Action

• Direct Xa inhibition

Half-Life

• 12 hours

Metabolism

• 25% Renal,Biliary
• Not removed by HD 

Dosing – Adult

• NVAF: 5 mg BID
• VTE: 10 mg BID x 7 days, followed by 5 mg BID

Dosing – Pediatric

• Please refer to pediatric section for information on use in children

Monitoring

• Not required, can use: chromogenic anti-factor Xa or mass spectrometry

*The International Society on Thrombosis and Haemostasis (ISTH) 2016 guidelines suggest avoiding NOACs in patients with BMI >40 kg/m2 or weight >120 kg due to lack of clinical data