Mechanism of Action
- Direct inhibition of thrombin
Half-Life
- 12-17 hours
Metabolism
- 80% Renal, Biliary 65% removed by HD
Dosing – Adult
- 80% Renal, Biliary 65% removed by HD
Dosing – Pediatric
- Please refer to pediatric section for information on use in children
Monitoring
- Not required, can use: thrombin time, APTT, Ecarin clotting time
*The International Society on Thrombosis and Haemostasis (ISTH) 2016 guidelines suggest avoiding NOACs in patients with BMI >40 kg/m2 or weight >120 kg due to lack of clinical data
