to Warfarin

• Stop Apixaban
• If continuous anticoagulation (AC) needed, start Warfarin with parenteral anticoagulant at next scheduled dose

to Heparin (CI)

• Stop Apixaban
• Start CI Heparin without a bolus at next scheduled dose

to LMWH

• Stop Apixaban
• Start LMWH at next scheduled dose

to Dabigatran

• Stop Apixaban
• Start Dabigatran at next scheduled dose

to Apixaban

• N/A

to Rivaroxaban

• Stop Apixaban
• Start Rivaroxaban <2 hours before next scheduled dose

to Edoxoban

• Stop Apixaban
• Start Edoxaban at time of next scheduled dose

*Note: Dabigatran, Rivaroxaban, Edoxaban, and Apixaban affect the INR; measuring the INR during coadministration with warfarin therapy may not be useful for determining an appropriate dose of warfarin. To minimize this effect, check INR at trough level of respective medication