Mechanism of Action

• Nonglycosylated form of TPA produced by rDNA technology using E. coli. Local fibrinolysis by binding to fibrin, converts entrapped plasminogen to plasmin

Half-Life

• 13-16 minutes

Metabolism

• Inactivated by blood components C1 inactivator, alpha-1- antitrypsin, alpha-2- antiplasmin. Excreted in feces and urine

Dosing – Adult

• STEMI: I.V.: 10 unit bolus over 2 min x2, 30 minutes apart; withhold 2nd dose if serious bleeding or anaphylaxis occurs.

Dosing – Pediatric

• N/A

Monitoring

• PT
• APTT