Mechanism of Action

• Promotes initiation of fibrinolysis by binding to fibrin and converting plasminogen to plasmin. More fibrin specific and resistant to PAI-1 than alteplase

Half-Life

• 20-24 minutes

Metabolism

• Primarily Hepatic

Dosing – Adult

• STEMI: I.V. Administer as a single bolus over 5 seconds
  • <60 kg: 30 mg
  • ≥60 to <70 kg: 35 mg
  • ≥70 to <80 kg: 40 mg
  • ≥80 to <90 kg: 45 mg
  • ≥90 kg:50 mg
• Total dose should not exceed 50 mg; should be administered with 30 minutes of hospital arrival

Dosing – Pediatric

• N/A

Monitoring

• PT
• APTT